Oh man, I've actually booked a week off work for this. Not expecting any launch issues (yes I do remember New Vegas) so fingers and legs crossed on that one innit.
I played Fallout 3 on the Xbox360, it was one of the games I bought with the console. But I've recently been playing it on PC and didn't realise how much better it looks even without mods.
I'm 20 hours into my PC run-through and I just went high in medicine, small guns and repair to begin with. Now I'm bumping up science and lockpicking.
I have a scoped magnum which I'm relying on a fair amount.
I too I have never blown up Megaton