Looking at the skills as I unlock the runes, I want to say I went with this:
Darts - Flaming Dart rune (Setting shit on fire is handy until you hit the demon levels, they still take damage, only slightly less than normal, not enough to make you change the rune though)
Grasp of the Dead - Death is Life Rune (As it damages it drops health and summons more dogs. This was OP as hell at release, and I attribute it how I beat Diablo so quickly. That was 2 years ago though, no idea how good it si now)
Zombie Dogs - ???
Sacrifice or Soul Harvest. I remember exploding my dogs a lot once they got surrounded, not 100% though as the Int buff is nice on Soul Harvest. I most likely changed it a lot depending on the situation
Acid Cloud
Gargantuan (Big Bad Voodoo when grouped)
You can target Acid Cloud directly over your Grasp of the dead, just hit one, and then the other on the same mob. Stand back spamming darts while your pets run around fighting.
Sacrifice your dogs as you need to for bosses, and then re-summon. I don't recall the cooldown being that bad when I did this before.
As always, stack INT gear!
I will post specific runes where not mentioned as I unlock them