It took me about a month to get used to using mine back in my Pre-WOW Days. Once I sorted it out though, I use it incessantly. Hell I code with it.
The software will load profiles based on what program you have running, so you can have different button configs for every game.
Now that I think about it though, this is left over from the Belkin days of making these,e and I think the Razer removes that, luckily the drivers are the same, so the button software didn't change for me
For me, the buttun directly above the directional pad is my knife button, then the one below the D-pad is jump
I then use WASD arrows ( you can see them there)
05 is reload,
03 is grenade,
10 is equipment slot 1,
06 is equpiment slot 2
13 is crouch/ prone
and 11 is Run
Mouse controls shooting, zoom, and weapon select