Cal, good find. I didn't hear the Sanctuary part. That's pretty cool that they hinted at that already.
Sebba, Negan is a badass and you'll meet him soon enough if you read the comics further.
As for the new virus, I actually like it. Think about it, they are now living in a world where the dead have arisen and there is blood, guts, dirty people, dirty water, lack of food, no medicine. How could there not be some deadly virus happening? I really doubt we'll lose Glenn and Hershel. I could be wrong but I saw on the sneak peek into next week's episode, Daryl and Pips are in the medical college. I'm pretty sure they'll get the medicine and be able to save at least one of them. Plus they had wild berry tea to save them!!!